background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

breast cancer  patients  are  susceptible to  infections such  as  candidiasis. due  to  the importance and the role of matrix metalloproteinases (mmp) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of mmps -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in breast cancer bearing mice in the presence of systemic candida ...

background: trichophyton verrucosum is a zoophilic fungus with a worldwide distribution. our aim was to investigate the proliferative effect of antigenic compounds of t. verrucosum on dermis fibro blasts and endothelial cells. methods: t. verrucosum was cultured in scc medium and was then transferred to a broth medium. surface antigens of this fungus were separated using the freeze and thaw met...

objective(s): osteoarthritis (oa), as a known degenerative joint disease, is the most common form of arthritis. in this study, we aimed to elucidate unclear pathogenesis of oa. materials and methods: rabbit models of oa were established by the transection of the anterior cruciate ligament. rabbits were randomly divided into three equal groups: the experimental group (oa modeling, treated with e...

this study was conducted to examine if allergic contact dermatitis (acd) alters the expression of mmps in human dermal fibroblasts. fibroblasts are the primary source for mmp and matrix production in skin. mmps are known to involve in a number of physiological and pathological processes. some published data indicated a gelatinase-like activity in acute and chronic phases of allergic contact der...

controversial immunomodulatory properties of bee venom (bv) have provided an appropriate field for more investigation. the aim of present research was to verify the effects of honeybee venom on matrix metalloproteinase activity and interferon production as well as cell proliferation in monocyte and fibroblast cell lines. the monocyte and fibroblast cell lines (k562, ht-1080, wehi-164) were used...

abstract introduction: matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. we studied the role of mmp-2 on the analgesic effects of nnos inhibitor. methods: considering that nitric oxide has many roles in pain processing, we studied the csf levels of mmp-2 af...

introduction: exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. the aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (vegf) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( mmp-2 and mmp-9), as the degrading ...

introduction: squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. the aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (oscc).   materials and met...